Domain

Endo-alpha-N-acetylgalactosaminidase (IPR025706)

Short name: Endoa_GalNAc

Domain relationships

None.

Description

Virulence of pathogenic organisms such as the Gram-positive Streptococcus pneumoniae is largely determined by the ability to degrade host glycoproteins and to metabolise the resultant carbohydrates.

This domain represents the enzymatic region (EC:3.2.1.97) of cell surface glycoside hydrolases from family GH101 [PMID: 20556855] that specifically remove the T-antigen disaccharide (Gal-beta-1,3-GalNAc-alpha) linked to serine or threonine residues of mucin-type glycoproteins [PMID: 18784084]. This reaction is exemplified by the S. pneumoniae endo-alpha-N-acetylgalactosaminidase (SpGH101), where Asp764 is the catalytic nucleophile-base and Glu796 the catalytic proton donor [PMID: 19788271].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0033926 glycopeptide alpha-N-acetylgalactosaminidase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD
Pfam