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Human AlkB homolog ALKBH6 in complex with alpha-katoglutarate and Mn

X-ray diffraction
1.75Å resolution
PDB entry 7vjv coloured by chain, front view.
PDB entry 7vjv coloured by chain, side view.
PDB entry 7vjv coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Alpha-ketoglutarate-dependent dioxygenase alkB homolog 6
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Multimeric state: monomeric
Accessible surface area: 11723.49 Å2
Buried surface area: 547.17 Å2
Dissociation area: 221.26 Å2
Dissociation energy (ΔGdiss): 2.32 kcal/mol
Dissociation entropy (TΔSdiss): 2.28 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-174717

Macromolecules

Alpha-ketoglutarate-dependent dioxygenase alkB homolog 6
Chain: A
Length: 246 amino acids
Theoretical weight: 27.47 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: Q3KRA9 (Residues: 1-238; Coverage: 100%)
Gene names: ABH6, ALKBH6
Pfam: 2OG-Fe(II) oxygenase superfamily
InterPro:
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 6 in PDB entry 7vjv, assembly 1, front view.
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 6 in PDB entry 7vjv, assembly 1, side view.
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 6 in PDB entry 7vjv, assembly 1, top view.
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