Domain

Alpha-ketoglutarate-dependent dioxygenase AlkB-like (IPR027450)

Short name: AlkB-like

Domain relationships

None.

Description

AlkB is a DNA repair enzyme that removes methyl adducts and some larger alkylation lesions from endocyclic positions on purine and pyrimidine bases. It is a dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron [PMID: 12226668, PMID: 21068844]. The catalytic core of AlkB is homologous to other Fe-2OG dioxygenases [PMID: 16513174]. Two discrete global conformations have been observed for AlkB, differing in accessibility of a putative oxygen-diffusion tunnel [PMID: 19706517].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam