› 7n15

Electron Microscopy
2.9Å resolution

Structure of TAX-4_R421W w/cGMP open state

Released:
DOI: 10.2210/pdb7n15/pdb
PDB entry 7n15 coloured by chain, front view.
PDB entry 7n15 coloured by chain, side view.
PDB entry 7n15 coloured by chain, top view.
Source organism: Caenorhabditis elegans
Primary publication:
Structural and functional characterization of an achromatopsia-associated mutation in a phototransduction channel.
Zheng X, Li H, Hu Z, Su D, Yang J
Commun Biol 5 190 (2022)
PMID: 35233102
Related structures: EMD-24113

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169922 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cyclic nucleotide-gated cation channel Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 738 amino acids
Theoretical weight: 84.33 KDa
Source organism: Caenorhabditis elegans
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q03611 (Residues: 1-733; Coverage: 100%)
Gene names: ZC84.2, tax-4
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand PCG 4 x PCG
Ligand CPL 20 x CPL
Ligand PX2 4 x PX2
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.9Å
Relevant EMDB volumes: EMD-24113
Expression system: Spodoptera frugiperda

Quick links

Citations

2 review citations

Biology, Pathobiology and Gene Therapy of CNG Channel-Related Retinopathies.
Gerhardt et al. (2023)
1 more

4 mentions without citation

Structural basis of properties, mechanisms, and channelopathy of cyclic nucleotide-gated channels.
Hu et al. (2023)
3 more