Domain

Ion transport domain (IPR005821)

Short name: Ion_trans_dom

Domain relationships

None.

Description

This domain is found in sodium, potassium, and calcium ion channels proteins. The proteins have 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some Na channel proteins the domain is repeated four times, whereas in others (e.g. K channels) the protein forms a tetramer in the membrane. A bacterial structure of the protein is known for the last two helices but is not included in the Pfam family due to it lacking the first four helices.

GO terms

Biological Process

GO:0006811 ion transport
GO:0055085 transmembrane transport

Molecular Function

GO:0005216 ion channel activity

Cellular Component

GO:0016020 membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam