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Succinyl-CoA synthase from Francisella tularensis

Source organism: Francisella tularensis subsp. tularensis SCHU S4
Biochemical function: metal ion binding
Biological process: tricarboxylic acid cycle
Cellular component: succinate-CoA ligase complex

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EC 6.2.1.5: Succinate--CoA ligase (ADP-forming)

Reaction catalysed:
ATP + succinate + CoA = ADP + phosphate + succinyl-CoA
Systematic name:
Succinate:CoA ligase (ADP-forming)
Alternative Name(s):
  • A-SCS
  • A-STK (adenin nucleotide-linked succinate thiokinase)
  • STK
  • Succinate thiokinase
  • Succinic thiokinase
  • Succinyl coenzyme A synthetase
  • Succinyl coenzyme A synthetase (adenosine diphosphate-forming)
  • Succinyl-CoA synthetase
  • Succinyl-CoA synthetase (ADP-forming)

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00549
Domain description: CoA-ligase
Occurring in:
  1. Succinate--CoA ligase [ADP-forming] subunit alpha
  2. Succinate--CoA ligase [ADP-forming] subunit beta
The deposited structure of PDB entry 6pfn contains 2 copies of Pfam domain PF00549 (CoA-ligase) in Succinate--CoA ligase [ADP-forming] subunit alpha. Showing 1 copy in chain A.
The deposited structure of PDB entry 6pfn contains 2 copies of Pfam domain PF00549 (CoA-ligase) in Succinate--CoA ligase [ADP-forming] subunit beta. Showing 1 copy in chain D.

PF08442
Domain description: ATP-grasp domain
Occurring in:
  1. Succinate--CoA ligase [ADP-forming] subunit beta
The deposited structure of PDB entry 6pfn contains 2 copies of Pfam domain PF08442 (ATP-grasp domain) in Succinate--CoA ligase [ADP-forming] subunit beta. Showing 1 copy in chain D.

PF02629
Domain description: CoA binding domain
Occurring in:
  1. Succinate--CoA ligase [ADP-forming] subunit alpha
The deposited structure of PDB entry 6pfn contains 2 copies of Pfam domain PF02629 (CoA binding domain) in Succinate--CoA ligase [ADP-forming] subunit alpha. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR016102
Domain description: Succinyl-CoA synthetase-like
Occurring in:
  1. Succinate--CoA ligase [ADP-forming] subunit alpha
  2. Succinate--CoA ligase [ADP-forming] subunit beta
IPR005809
Domain description: Succinate--CoA ligase-like, beta subunit
Occurring in:
  1. Succinate--CoA ligase [ADP-forming] subunit beta
IPR005810
Domain description: Succinyl-CoA ligase, alpha subunit
Occurring in:
  1. Succinate--CoA ligase [ADP-forming] subunit alpha
IPR005811
Domain description: ATP-citrate synthase/succinyl-CoA ligase, C-terminal domain
Occurring in:
  1. Succinate--CoA ligase [ADP-forming] subunit alpha
  2. Succinate--CoA ligase [ADP-forming] subunit beta
IPR003781
Domain description: CoA-binding
Occurring in:
  1. Succinate--CoA ligase [ADP-forming] subunit alpha
IPR017866
Domain description: Succinyl-CoA synthetase, beta subunit, conserved site
Occurring in:
  1. Succinate--CoA ligase [ADP-forming] subunit beta
IPR013815
Domain description: ATP-grasp fold, subdomain 1
Occurring in:
  1. Succinate--CoA ligase [ADP-forming] subunit beta
IPR011761
Domain description: ATP-grasp fold
Occurring in:
  1. Succinate--CoA ligase [ADP-forming] subunit beta
IPR013650
Domain description: ATP-grasp fold, succinyl-CoA synthetase-type
Occurring in:
  1. Succinate--CoA ligase [ADP-forming] subunit beta
IPR017440
Domain description: ATP-citrate lyase/succinyl-CoA ligase, active site
Occurring in:
  1. Succinate--CoA ligase [ADP-forming] subunit alpha
IPR033847
Domain description: ATP-citrate lyase/succinyl-CoA ligase, conserved site
Occurring in:
  1. Succinate--CoA ligase [ADP-forming] subunit alpha
IPR036291
Domain description: NAD(P)-binding domain superfamily
Occurring in:
  1. Succinate--CoA ligase [ADP-forming] subunit alpha

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