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A mutant form of M. tb toxin MazEF-mt1

X-ray diffraction
1.9Å resolution
PDB entry 6l2a coloured by chain, front view.
PDB entry 6l2a coloured by chain, side view.
PDB entry 6l2a coloured by chain, top view.
Source organism: Mycobacterium tuberculosis
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Endoribonuclease MazF9
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Multimeric state: homo dimer
Accessible surface area: 10960.98 Å2
Buried surface area: 1702.05 Å2
Dissociation area: 851.03 Å2
Dissociation energy (ΔGdiss): 8.65 kcal/mol
Dissociation entropy (TΔSdiss): 11.28 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-159809

Macromolecules

Endoribonuclease MazF9
Chain: A
Length: 122 amino acids
Theoretical weight: 13 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli
UniProt:
  • Canonical: P71650 (Residues: 2-118; Coverage: 99%)
Gene names: Rv2801c, mazF-mt1, mazF9
Pfam: PemK-like, MazF-like toxin of type II toxin-antitoxin system
InterPro:
Endoribonuclease MazF9 in PDB entry 6l2a, assembly 1, front view.
Endoribonuclease MazF9 in PDB entry 6l2a, assembly 1, side view.
Endoribonuclease MazF9 in PDB entry 6l2a, assembly 1, top view.
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