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Complex structure of FAK FAT domain and DCC P3 motif

X-ray diffraction
2.497Å resolution
PDB entry 6bz3 coloured by chain, front view.
PDB entry 6bz3 coloured by chain, side view.
PDB entry 6bz3 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Netrin receptor DCC and Focal adhesion kinase 1
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Multimeric state: hetero tetramer
Accessible surface area: 15055.06 Å2
Buried surface area: 6976.88 Å2
Dissociation area: 784.67 Å2
Dissociation energy (ΔGdiss): 8.43 kcal/mol
Dissociation entropy (TΔSdiss): 9.02 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-152689

Macromolecules

Focal adhesion kinase 1
Chains: A, C
Length: 126 amino acids
Theoretical weight: 14.01 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P34152 (Residues: 921-1046; Coverage: 12%)
Gene names: Fadk, Fak, Fak1, Kiaa4203, Ptk2
Pfam: Focal adhesion targeting region
InterPro:
CATH: Nucleotidyltransferases domain 2
Focal adhesion kinase 1 in PDB entry 6bz3, assembly 1, front view.
Focal adhesion kinase 1 in PDB entry 6bz3, assembly 1, side view.
Focal adhesion kinase 1 in PDB entry 6bz3, assembly 1, top view.
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Netrin receptor DCC
Chains: B, D
Length: 23 amino acids
Theoretical weight: 2.45 KDa
Source organism: Rattus norvegicus
Expression system: Not provided
UniProt:
  • Canonical: Q63155 (Residues: 1421-1443; Coverage: 2%)
Gene name: Dcc
InterPro: Neogenin, C-terminal
Netrin receptor DCC in PDB entry 6bz3, assembly 1, front view.
Netrin receptor DCC in PDB entry 6bz3, assembly 1, side view.
Netrin receptor DCC in PDB entry 6bz3, assembly 1, top view.
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