Domain

Focal adhesion kinase, targeting (FAT) domain (IPR005189)

Short name: Focal_adhesion_kin_target_dom

Domain relationships

None.

Description

Focal adhesion kinase (FAK) is a tyrosine kinase found in focal adhesions, intracellular signalling complexes that are formed following engagement of the extracellular matrix by integrins. The C-terminal "focal adhesion targeting" (FAT) region is necessary and sufficient for localizing FAK to focal adhesions. The crystal structure of FAT shows it forms a four-helix bundle that resembles those found in two other proteins involved in cell adhesion, alpha-catenin and vinculin [PMID: 11799401]. The binding of FAT to the focal adhesion protein, paxillin, requires the integrity of the helical bundle, whereas binding to another focal adhesion protein, talin, does not.

GO terms

Biological Process

GO:0006468 protein phosphorylation
GO:0007172 signal complex assembly

Molecular Function

GO:0004713 protein tyrosine kinase activity
GO:0004871 signal transducer activity

Cellular Component

GO:0005925 focal adhesion

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
SUPERFAMILY
ProDom
Pfam