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Influenza A M2 transmembrane domain bound to amantadine

X-ray diffraction
1.995Å resolution
PDB entry 6bkk coloured by chain, front view.
PDB entry 6bkk coloured by chain, side view.
PDB entry 6bkk coloured by chain, top view.
Source organism: Influenza A virus
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Matrix protein 2
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Multimeric state: homo tetramer
Accessible surface area: 5365.61 Å2
Buried surface area: 5466.94 Å2
Dissociation area: 2,626.34 Å2
Dissociation energy (ΔGdiss): 35.78 kcal/mol
Dissociation entropy (TΔSdiss): 25.73 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-192958
Assembly 2
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Assembly Name: Matrix protein 2
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Multimeric state: homo tetramer
Accessible surface area: 5388.44 Å2
Buried surface area: 5587.25 Å2
Dissociation area: 2,631.16 Å2
Dissociation energy (ΔGdiss): 35.01 kcal/mol
Dissociation entropy (TΔSdiss): 25.79 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-192958

Macromolecules

Matrix protein 2
Chains: A, B, C, D, E, F, G, H
Length: 27 amino acids
Theoretical weight: 2.75 KDa
Source organism: Influenza A virus
Expression system: Not provided
UniProt:
  • Canonical: Q9Q0L9 (Residues: 22-46; Coverage: 26%)
Gene name: M
InterPro: Influenza virus matrix protein 2
Matrix protein 2 in PDB entry 6bkk, assembly 1, front view.
Matrix protein 2 in PDB entry 6bkk, assembly 1, side view.
Matrix protein 2 in PDB entry 6bkk, assembly 1, top view.
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