Influenza virus matrix protein 2 (IPR002089)

Short name: Flu_M2

Overlapping homologous superfamilies


Family relationships



This entry contains Influenza virus matrix protein 2. It is an integral membrane protein that is expressed on the infected cell surface and incorporated into virions where it is a minor component. The protein spans the viral membrane with an extracellular amino-terminus and a cytoplasmic carboxy-terminus. The transmembrane domain of the M2 protein forms the channel pore. The M2 protein, which forms a homotetramer, has H+ ion channel which was found to be regulated by pH [PMID: 9360376 and may have a pivotal role in the biology of Influenza virus infection [PMID: 1374685].

GO terms

Biological Process

GO:1902600 proton transmembrane transport

Molecular Function

GO:0015078 proton transmembrane transporter activity

Cellular Component

GO:0033644 host cell membrane
GO:0055036 virion membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.