› 6z4y

X-ray diffraction
2.25Å resolution

Crystal structure of Aurora A (STK6) in complex with macrocycle ODS2003208

Released:
DOI: 10.2210/pdb6z4y/pdb
PDB entry 6z4y coloured by chain, front view.
PDB entry 6z4y coloured by chain, side view.
PDB entry 6z4y coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Chaikuad A, Benderitter P, Hoflack J, Denis A, Knapp S, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127232 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Aurora kinase A Chain: A
Molecule details ›
Chain: A
Length: 285 amino acids
Theoretical weight: 32.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O14965 (Residues: 122-403; Coverage: 70%)
Gene names: AIK, AIRK1, ARK1, AURA, AURKA, AYK1, BTAK, IAK1, STK15, STK6
Sequence domains: Protein kinase domain

Ligands and Environments

3 bound ligands:
Ligand CIT 2 x CIT
Ligand EDO 5 x EDO
Ligand Q7Q 1 x Q7Q
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P6122
Unit cell:
a: 82.83Å b: 82.83Å c: 173.301Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.209 0.206 0.257
Expression system: Escherichia coli BL21(DE3)

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