Family

Aurora kinase (IPR030616)

Short name: Aur

Family relationships

Description

Aurora kinase was discovered by Glover and colleagues in a screen for genes required to maintain the centrosome cycle in Drosophila [PMID: 7720077]. Its yeast homologue Ipl1 (also known as spindle assembly checkpoint kinase) was found to regulate chromosome segregation [PMID: 8007975]. Subsequently, three mammal Aurora kinases, Aurora A, B and C, have been identified.

They are highly conserved serine/threonine kinases that regulate chromosomal alignment and segregation during mitosis and meiosis [PMID: 23516109]. They all contain a protein kinase domain and a destruction box (D-box) recognised by the multi-subunit E3-ubiquitin ligase anaphase promoting complex/cyclosome (APC/C), which mediates their proteasomal degradation. However, their N-terminal domains share little sequence identity and confer unique protein-protein interaction abilities among the Aurora kinases [PMID: 14625535].

Functionally, Aurora A associates with centrosome, while Aurora B and Aurora C are parts of the chromosome passenger complex (CPC) [PMID: 23516109, PMID: 15316025]. Aurora C plays a role in the meiotic cell cycle, but does not seem to be essential for cell divisions in somatic cells [PMID: 23516109].

GO terms

Biological Process

GO:0007049 cell cycle

Molecular Function

GO:0004672 protein kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER