Aurora kinase A (IPR030611)
Short name: AURKA
Overlapping homologous superfamilies
- Protein kinase-like domain superfamily (IPR011009)
- Protein kinase domain (IPR000719)
- Aurora kinase A (IPR030611)
Aurora kinase A (AURKA, also known as Aurora 2) is a mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression. It associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in regulating centrosome maturation and separation and bipolar spindle assembly [PMID: 9245792, PMID: 19075002]. It also plays an important role in the spindle checkpoint regulation [PMID: 19221504]. Aurora A promotes mitotic entry by controlling activation of Cyclin-B/Cdk-1. It regulates the progression of mitosis by phosphorylation of multiple substrates, such as Polo-like kinase-1, ajuba, enhancer of filamentation 1, BORA, TPX2, PLK-1, astrin, growth arrest and DNA damage-inducible 45alpha, transforming acidic coiled-coil containing protein 3 (TACC3) and centrosomin [PMID: 24632603]. During mitotic exit, AURKA is targeted for degradation through its interaction with the multi-subunit E3-ubiquitin ligase anaphase promoting complex/cyclosome (APC/C) [PMID: 15536123].
The Aurora kinases are highly conserved serine/threonine kinases that regulate chromosomal alignment and segregation during mitosis and meiosis. Three mammalian Aurora kinases, Aurora A, B and C, have been identified. They all contain a protein kinase domain and a destruction box (D-box) recognised by the multi-subunit E3-ubiquitin ligase anaphase promoting complex/cyclosome (APC/C), which mediates their proteasomal degradation. However, their N-terminal domain share little sequence identity and confer unique protein-protein interaction abilities among the Aurora kinases [PMID: 14625535]. They are differentially expressed at high levels in rapidly dividing tissues such as hematopoietic cells (A and B) and germ cells (C only). Their expression is low or absent in most adult tissues due to their lower rates of proliferation [PMID: 24632603].
GO:0007098 centrosome cycle
GO:0051321 meiotic cell cycle
GO:0000212 meiotic spindle organization
GO:0000226 microtubule cytoskeleton organization
GO:0000278 mitotic cell cycle
GO:0007100 mitotic centrosome separation
GO:0007052 mitotic spindle organization
GO:0004672 protein kinase activity
No terms assigned in this category.
- cd14116 (STKc_Aurora-A)