Structure analysis

Crystal structure of FTO in complex with m6dA modified ssDNA

X-ray diffraction
3.3Å resolution
Assembly composition:
hetero tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule
1 distinct DNA molecule

Assemblies

Assembly 1
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Multimeric state: hetero tetramer
Accessible surface area: 36483.83 Å2
Buried surface area: 9546.47 Å2
Dissociation area: 4,086.99 Å2
Dissociation energy (ΔGdiss): -0.71 kcal/mol
Dissociation entropy (TΔSdiss): 33.83 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-119522
Assembly 2 (preferred)
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Multimeric state: hetero tetramer
Accessible surface area: 37055.09 Å2
Buried surface area: 9446.22 Å2
Dissociation area: 4,031.13 Å2
Dissociation energy (ΔGdiss): -6.09 kcal/mol
Dissociation entropy (TΔSdiss): 33.84 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-119522

Macromolecules

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Name: DNA (5'-D(P*TP*CP*TP*(6MA)P*TP*AP*TP*CP*G)-3')
Representative chains: B, D, F, H
Source organism: DNA launch vector pDE-GFP2 [415098]
Expression system: Not provided
Length: 9 nucleotides
Theoretical weight: 2.72 KDa

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