Alpha-ketoglutarate-dependent dioxygenase FTO, C-terminal (IPR024366)

Short name: FTO_C

Overlapping homologous superfamilies

Domain relationships



Alpha-ketoglutarate-dependent dioxygenase FTO, also known as Fat mass and obesity-associated protein, is a nucleus protein which belongs to the FTO family. This enzyme is a dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation [PMID: 17991826]. FTO activity is highest towards single-stranded RNA containing 3-methyluracil, followed by single-stranded DNA containing 3-methylthymine. FTO has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine [PMID: 18775698]. FTO has no activity towards 1-methylguanine. It has no detectable activity towards double-stranded DNA. FTO requires molecular oxygen, alpha-ketoglutarate and iron. FTO contributes to the regulation of the global metabolic rate, energy expenditure and energy homeostasis. It contributes to the regulation of body size and body fat accumulation as well [PMID: 19234441].

This domain is found at the C terminus of the FTO protein. The N-terminal domain of this protein is a DNA demethylase, and this domain is found to associate with the N-terminal domain in the crystal structure [PMID: 20376003]. This domain is alpha helical with three helices that form a bundle [PMID: 20376003].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.