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Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment

X-ray diffraction
2.12Å resolution
PDB entry 5oro coloured by chain, front view.
PDB entry 5oro coloured by chain, side view.
PDB entry 5oro coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Aurora kinase A
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Multimeric state: monomeric
PDBe Complex ID: PDB-CPX-127232

Macromolecules

Aurora kinase A
Chain: A
Length: 265 amino acids
Theoretical weight: 30.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O14965 (Residues: 127-391; Coverage: 66%)
Gene names: AIK, AIRK1, ARK1, AURA, AURKA, AYK1, BTAK, IAK1, STK15, STK6
Pfam: Protein kinase domain
InterPro:
CATH:
Aurora kinase A in PDB entry 5oro, assembly 1, front view.
Aurora kinase A in PDB entry 5oro, assembly 1, side view.
Aurora kinase A in PDB entry 5oro, assembly 1, top view.
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