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The molecular tweezer CLR01 stabilizes a disordered protein-protein interface

X-ray diffraction
2.45Å resolution
PDB entry 5m36 coloured by chain, front view.
PDB entry 5m36 coloured by chain, side view.
PDB entry 5m36 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: 14-3-3 protein zeta/delta and M-phase inducer phosphatase 3
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Multimeric state: hetero tetramer
Accessible surface area: 24016.75 Å2
Buried surface area: 6167.83 Å2
Dissociation area: 548.47 Å2
Dissociation energy (ΔGdiss): 1.57 kcal/mol
Dissociation entropy (TΔSdiss): 7.17 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-151706

Macromolecules

14-3-3 protein zeta/delta
Chains: A, B
Length: 229 amino acids
Theoretical weight: 26.2 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P63104 (Residues: 2-230; Coverage: 94%)
Gene name: YWHAZ
Pfam: 14-3-3 protein
InterPro:
CATH: 14-3-3 domain
14-3-3 protein zeta/delta in PDB entry 5m36, assembly 1, front view.
14-3-3 protein zeta/delta in PDB entry 5m36, assembly 1, side view.
14-3-3 protein zeta/delta in PDB entry 5m36, assembly 1, top view.
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M-phase inducer phosphatase 3
Chains: C, D
Length: 38 amino acids
Theoretical weight: 4.58 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P30307 (Residues: 207-244; Coverage: 8%)
Gene name: CDC25C
Pfam: M-phase inducer phosphatase
InterPro: M-phase inducer phosphatase
M-phase inducer phosphatase 3 in PDB entry 5m36, assembly 1, front view.
M-phase inducer phosphatase 3 in PDB entry 5m36, assembly 1, side view.
M-phase inducer phosphatase 3 in PDB entry 5m36, assembly 1, top view.
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