Function and Biology

Crystal structure of photoinhibitable Intersectin1 containing C450M mutant LOV2 domain

Source organisms:
Biochemical function: guanyl-nucleotide exchange factor activity
Biological process: intracellular signal transduction
Cellular component: not assigned

EC 2.7.11.1: Non-specific serine/threonine protein kinase

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Systematic name:
ATP:protein phosphotransferase (non-specific)
Alternative Name(s):
  • A-kinase
  • AP50 kinase
  • ATP-protein transphosphorylase
  • Beta-IIPKC
  • Beta-adrenergic receptor kinase
  • CK-2
  • CKI
  • CKII
  • Calcium-dependent protein kinase C
  • Calcium/phospholipid-dependent protein kinase
  • Casein kinase
  • Casein kinase (phosphorylating)
  • Casein kinase 2
  • Casein kinase I
  • Casein kinase II
  • Cyclic AMP-dependent protein kinase
  • Cyclic AMP-dependent protein kinase A
  • Cyclic monophosphate-dependent protein kinase
  • Cyclic nucleotide-dependent protein kinase
  • Cyclin-dependent kinase
  • Cytidine 3',5'-cyclic monophosphate-responsive protein kinase
  • Dsk1
  • Epsilon PKC
  • Glycogen synthase A kinase
  • Glycogen synthase a kinase
  • Glycogen synthase kinase
  • HIPK2
  • Hpr kinase
  • Hydroxyalkyl-protein kinase
  • M phase-specific cdc2 kinase
  • MAPK
  • Mitogen-activated S6 kinase
  • Mitogen-activated protein kinase
  • P82 kinase
  • PKA
  • PKC
  • Phosphorylase B kinase kinase
  • Phosphorylase b kinase kinase
  • Phosphorylase b kinase kinase
  • Protein glutamyl kinase
  • Protein kinase (phosphorylating)
  • Protein kinase A
  • Protein kinase CK2
  • Protein kinase p58
  • Protein phosphokinase
  • Protein serine kinase
  • Protein serine-threonine kinase
  • Protein-aspartyl kinase
  • Protein-cysteine kinase
  • Protein-serine kinase
  • Prp4 protein kinase
  • Raf kinase
  • Raf-1
  • Ribosomal S6 protein kinase
  • Ribosomal protein S6 kinase II
  • STK32
  • Serine kinase
  • Serine protein kinase
  • Serine(threonine) protein kinase
  • Serine-specific protein kinase
  • Serine/threonine protein kinase
  • T-antigen kinase
  • Threonine-specific protein kinase
  • Twitchin kinase
  • Type-2 casein kinase
  • WEE1Hu
  • Wee 1-like kinase
  • Wee-kinase
  • cAMP-dependent protein kinase
  • cAMP-dependent protein kinase A
  • cGMP-dependent protein kinase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF16652
Domain description: Pleckstrin homology domain
Occurring in:
  1. Intersectin-1; non-specific serine/threonine protein kinase
The deposited structure of PDB entry 5hzi contains 2 copies of Pfam domain PF16652 (Pleckstrin homology domain) in Intersectin-1. Showing 1 copy in chain A.

PF13426
Domain description: PAS domain
Occurring in:
  1. Intersectin-1; non-specific serine/threonine protein kinase
The deposited structure of PDB entry 5hzi contains 2 copies of Pfam domain PF13426 (PAS domain) in Intersectin-1. Showing 1 copy in chain A.

PF00621
Domain description: RhoGEF domain
Occurring in:
  1. Intersectin-1; non-specific serine/threonine protein kinase
The deposited structure of PDB entry 5hzi contains 2 copies of Pfam domain PF00621 (RhoGEF domain) in Intersectin-1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000219
Domain description: Dbl homology (DH) domain
Occurring in:
  1. Intersectin-1; non-specific serine/threonine protein kinase
IPR000014
Domain description: PAS domain
Occurring in:
  1. Intersectin-1; non-specific serine/threonine protein kinase
IPR001849
Domain description: Pleckstrin homology domain
Occurring in:
  1. Intersectin-1; non-specific serine/threonine protein kinase
IPR035899
Domain description: Dbl homology (DH) domain superfamily
Occurring in:
  1. Intersectin-1; non-specific serine/threonine protein kinase
IPR011993
Domain description: PH-like domain superfamily
Occurring in:
  1. Intersectin-1; non-specific serine/threonine protein kinase
IPR001331
Domain description: Guanine-nucleotide dissociation stimulator, CDC24, conserved site
Occurring in:
  1. Intersectin-1; non-specific serine/threonine protein kinase
IPR001610
Domain description: PAC motif
Occurring in:
  1. Intersectin-1; non-specific serine/threonine protein kinase
IPR000700
Domain description: PAS-associated, C-terminal
Occurring in:
  1. Intersectin-1; non-specific serine/threonine protein kinase
IPR035965
Domain description: PAS domain superfamily
Occurring in:
  1. Intersectin-1; non-specific serine/threonine protein kinase

Structure domains

CATH CATH domains
1.20.900.10
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Dbl Homology Domain; Chain A
Homology: Dbl homology (DH) domain
Occurring in:
  1. Intersectin-1; non-specific serine/threonine protein kinase
The deposited structure of PDB entry 5hzi contains 1 copy of CATH domain 1.20.900.10 (Dbl Homology Domain; Chain A) in Intersectin-1. Showing 1 copy in chain B.
2.30.29.30
Class: Mainly Beta
Architecture: Roll
Topology: PH-domain like
Homology: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Occurring in:
  1. Intersectin-1; non-specific serine/threonine protein kinase
The deposited structure of PDB entry 5hzi contains 1 copy of CATH domain 2.30.29.30 (PH-domain like) in Intersectin-1. Showing 1 copy in chain B.
3.30.450.20
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Beta-Lactamase
Homology: PAS domain
Occurring in:
  1. Intersectin-1; non-specific serine/threonine protein kinase
The deposited structure of PDB entry 5hzi contains 1 copy of CATH domain 3.30.450.20 (Beta-Lactamase) in Intersectin-1. Showing 1 copy in chain B.