› 5gpp

X-ray diffraction
2Å resolution

Crystal structure of zebrafish ASC PYD domain

Released:
DOI: 10.2210/pdb5gpp/pdb
PDB entry 5gpp coloured by chain, front view.
PDB entry 5gpp coloured by chain, side view.
PDB entry 5gpp coloured by chain, top view.
Source organisms:
Primary publication:
Functional and structural characterization of zebrafish ASC.
Li Y, Huang Y, Cao X, Yin X, Jin X, Liu S, Jiang J, Jiang W, Xiao TS, Zhou R, Cai G, Hu B, Jin T
FEBS J 285 2691-2707 (2018)
PMID: 29791979

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-199640 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Apoptosis-associated speck-like protein containing a CARD; Maltose/maltodextrin-binding periplasmic protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 468 amino acids
Theoretical weight: 51.35 KDa
Source organisms: Expression system: Bacteria Latreille et al. 1825
UniProt:
  • Canonical: P0AEX9 (Residues: 27-384; Coverage: 97%)
  • Canonical: Q9I9N6 (Residues: 3-88; Coverage: 42%)
Gene names: JW3994, asc, asc1, b4034, malE, pycard
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: GLC
Carbohydrate polymer
2 bound ligands:
Ligand SO4 5 x SO4
Ligand ACT 6 x ACT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P212121
Unit cell:
a: 51.31Å b: 121.28Å c: 176.87Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.203 0.201 0.252
Expression system: Bacteria Latreille et al. 1825

Quick links

Citations

6 review citations

The evolution of regulated cell death pathways in animals and their evasion by pathogens.
Tummers et al. (2022)
5 more

2 mentions without citation

Industrial IoT, Cyber Threats, and Standards Landscape: Evaluation and Roadmap.
Dhirani et al. (2021)
1 more