Family

Solute-binding family 1 (IPR006059)

Short name: SBP_1_dom

Family relationships

Description

Bacterial high affinity transport systems are involved in active transport of solutes across the cytoplasmic membrane. Most of the bacterial ABC (ATP-binding cassette) importers are composed of one or two transmembrane permease proteins, one or two nucleotide-binding proteins and a highly specific periplasmic solute-binding protein. In Gram-negative bacteria the solute-binding proteins are dissolved in the periplasm, while in archaea and Gram-positive bacteria, their solute-binding proteins are membrane-anchored lipoproteins [PMID: 8003968, PMID: 18310026].

On the basis of sequence similarities, the vast majority of these solute-binding proteins can be grouped into eight family clusters [PMID: 8336670], which generally correlate with the nature of the solute bound. This entry represents the family 1.

Family 1 members include:

  • Maltose/maltodextrin-binding proteins of Enterobacteriaceae (gene malE) [PMID: 7853407] and Streptococcus pneumoniae malX
  • Multiple oligosaccharide binding protein of Streptococcus mutans (gene msmE)
  • Escherichia coli glycerol-3-phosphate-binding protein
  • Serratia marcescens iron-binding protein (gene sfuA) and the homologous proteins (gene fbp) from Haemophilus influenzae and Neisseria
  • E. coli thiamine-binding protein (gene tbpA)

Interestingly, these thiamin-binding proteins share protein structural similarity with thiaminase-I. They may be evolved from a common ancestor [PMID: 18177053]. This entry also includes thiaminase-1 from Paenibacillus thiaminolyticus (Bacillus thiaminolyticus).

GO terms

Biological Process

GO:0006810 transport

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam