Conserved Site

Bacterial extracellular solute-binding family 1, conserved site (IPR006061)

Short name: Solute-bd_1_bac_CS


Bacterial high affinity transport systems are involved in active transport of solutes across the cytoplasmic membrane. The protein components of these traffic systems include one or two transmembrane protein components, one or two membrane-associated ATP-binding proteins and a high affinity periplasmic solute-binding protein. In Gram-positive bacteria which are surrounded by a single membrane and have therefore no periplasmic region the equivalent proteins are bound to the membrane via an N-terminal lipid anchor. These homologue proteins do not play an integral role in the transport process per se, but probably serve as receptors to trigger or initiate translocation of the solute through the membrane by binding to external sites of the integral membrane proteins of the efflux system. In addition at least some solute-binding proteins function in the initiation of sensory transduction pathways.

On the basis of sequence similarities, the vast majority of these solute-binding proteins can be grouped [PMID: 8336670] into eight families of clusters, which generally correlate with the nature of the solute bound. Family 1 currently includes the periplasmic proteins maltose/maltodextrin-binding proteins of enterobacteriaceae (gene malE) [PMID: 7853407] and Streptococcus pneumoniae malX; multiple oligo-saccharide binding protein of Streptococcus mutans (gene msmE); Escherichia coli glycerol-3-phosphate-binding protein; Serratia marcescens iron-binding protein (gene sfuA) and the homologous proteins (gene fbp) from Haemophilus influenzae and Neisseria; and E. coli thiamine-binding protein (gene tbpA).

GO terms

Biological Process

GO:0006810 transport

Molecular Function

GO:0005215 transporter activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns