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Structure of the SecA-SecY complex with a translocating polypeptide substrate

Source organisms:
Biochemical function: protein transmembrane transporter activity
Biological process: protein targeting
Cellular component: membrane

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EC 7.4.2.8: Protein-secreting ATPase

Reaction catalysed:
ATP + H(2)O + cellular protein(Side 1) = ADP + phosphate + cellular protein(Side 2)
Systematic name:
ATP phosphohydrolase (protein-secreting)

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF21090
Domain description: SecA P-loop domain
Occurring in:
  1. Protein translocase subunit SecA

PF00344
Domain description: SecY
Occurring in:
  1. Protein translocase subunit SecY
The deposited structure of PDB entry 5eul contains 1 copy of Pfam domain PF00344 (SecY) in Protein translocase subunit SecY. Showing 1 copy in chain B [auth Y].

PF00584
Domain description: SecE/Sec61-gamma subunits of protein translocation complex
Occurring in:
  1. Protein translocase subunit SecE
The deposited structure of PDB entry 5eul contains 1 copy of Pfam domain PF00584 (SecE/Sec61-gamma subunits of protein translocation complex) in Protein translocase subunit SecE. Showing 1 copy in chain C [auth E].

PF07516
Domain description: SecA Wing and Scaffold domain
Occurring in:
  1. Protein translocase subunit SecA
The deposited structure of PDB entry 5eul contains 1 copy of Pfam domain PF07516 (SecA Wing and Scaffold domain) in Protein translocase subunit SecA. Showing 1 copy in chain A.

PF01043
Domain description: SecA preprotein cross-linking domain
Occurring in:
  1. Protein translocase subunit SecA
The deposited structure of PDB entry 5eul contains 1 copy of Pfam domain PF01043 (SecA preprotein cross-linking domain) in Protein translocase subunit SecA. Showing 1 copy in chain A.

PF07517
Domain description: SecA DEAD-like domain
Occurring in:
  1. Protein translocase subunit SecA
The deposited structure of PDB entry 5eul contains 1 copy of Pfam domain PF07517 (SecA DEAD-like domain) in Protein translocase subunit SecA. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000185
Domain description: Protein translocase subunit SecA
Occurring in:
  1. Protein translocase subunit SecA
IPR002208
Domain description: SecY/SEC61-alpha family
Occurring in:
  1. Protein translocase subunit SecY
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Protein translocase subunit SecA
IPR001901
Domain description: Protein translocase complex, SecE/Sec61-gamma subunit
Occurring in:
  1. Protein translocase subunit SecE
IPR030659
Domain description: SecY conserved site
Occurring in:
  1. Protein translocase subunit SecY
IPR023201
Domain description: SecY domain superfamily
Occurring in:
  1. Protein translocase subunit SecY
IPR013106
Domain description: Immunoglobulin V-set domain
Occurring in:
  1. AYC08
IPR005807
Domain description: SecE subunit of protein translocation complex, bacterial-like
Occurring in:
  1. Protein translocase subunit SecE
IPR036266
Domain description: SecA, Wing/Scaffold superfamily
Occurring in:
  1. Protein translocase subunit SecA
IPR011116
Domain description: SecA Wing/Scaffold
Occurring in:
  1. Protein translocase subunit SecA
IPR011130
Domain description: SecA, preprotein cross-linking domain
Occurring in:
  1. Protein translocase subunit SecA
IPR011115
Domain description: SecA DEAD-like, N-terminal
Occurring in:
  1. Protein translocase subunit SecA
IPR026593
Domain description: Protein translocase subunit SecY
Occurring in:
  1. Protein translocase subunit SecY
IPR003599
Domain description: Immunoglobulin subtype
Occurring in:
  1. AYC08
IPR036179
Domain description: Immunoglobulin-like domain superfamily
Occurring in:
  1. AYC08
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. AYC08
IPR007110
Domain description: Immunoglobulin-like domain
Occurring in:
  1. AYC08
IPR038379
Domain description: SecE superfamily
Occurring in:
  1. Protein translocase subunit SecE
IPR020937
Domain description: SecA conserved site
Occurring in:
  1. Protein translocase subunit SecA
IPR001650
Domain description: Helicase, C-terminal domain-like
Occurring in:
  1. Protein translocase subunit SecA
IPR044722
Domain description: SecA, C-terminal helicase domain
Occurring in:
  1. Protein translocase subunit SecA
IPR036670
Domain description: SecA, preprotein cross-linking domain superfamily
Occurring in:
  1. Protein translocase subunit SecA
IPR014001
Domain description: Helicase superfamily 1/2, ATP-binding domain
Occurring in:
  1. Protein translocase subunit SecA
IPR014018
Domain description: SecA motor DEAD
Occurring in:
  1. Protein translocase subunit SecA

Structure domain

CATH CATH domain
2.60.40.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulins
Occurring in:
  1. AYC08
The deposited structure of PDB entry 5eul contains 1 copy of CATH domain 2.60.40.10 (Immunoglobulin-like) in AYC08. Showing 1 copy in chain D [auth V].

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