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Crystal structure of AKR1C3 complexed with glicazide

X-ray diffraction
2Å resolution
PDB entry 4zfc coloured by chain, front view.
PDB entry 4zfc coloured by chain, side view.
PDB entry 4zfc coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Aldo-keto reductase family 1 member C3
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Multimeric state: monomeric
Accessible surface area: 13664.17 Å2
Buried surface area: 1206.59 Å2
Dissociation area: 603.29 Å2
Dissociation energy (ΔGdiss): 9.12 kcal/mol
Dissociation entropy (TΔSdiss): 6.45 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-154612
Assembly 2
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Assembly Name: Aldo-keto reductase family 1 member C3
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Multimeric state: monomeric
Accessible surface area: 13931.9 Å2
Buried surface area: 1198.11 Å2
Dissociation area: 599.05 Å2
Dissociation energy (ΔGdiss): 8.41 kcal/mol
Dissociation entropy (TΔSdiss): 6.44 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-154612

Macromolecules

Aldo-keto reductase family 1 member C3
Chains: A, B
Length: 323 amino acids
Theoretical weight: 36.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P42330 (Residues: 1-323; Coverage: 100%)
Gene names: AKR1C3, DDH1, HSD17B5, KIAA0119, PGFS
Pfam: Aldo/keto reductase family
InterPro:
CATH: NADP-dependent oxidoreductase domain
Aldo-keto reductase family 1 member C3 in PDB entry 4zfc, assembly 1, front view.
Aldo-keto reductase family 1 member C3 in PDB entry 4zfc, assembly 1, side view.
Aldo-keto reductase family 1 member C3 in PDB entry 4zfc, assembly 1, top view.
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