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C-terminal mutant (W550N) of HCV/J4 RNA polymerase

X-ray diffraction
2.71Å resolution
PDB entry 4ry5 coloured by chain, front view.
PDB entry 4ry5 coloured by chain, side view.
PDB entry 4ry5 coloured by chain, top view.
Source organism: Hepatitis C virus isolate HC-J4
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: RNA-directed RNA polymerase
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Multimeric state: monomeric
Accessible surface area: 23673.97 Å2
Buried surface area: 1068.11 Å2
Dissociation area: 102.43 Å2
Dissociation energy (ΔGdiss): 7.63 kcal/mol
Dissociation entropy (TΔSdiss): -0.12 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-131655
Assembly 2
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Assembly Name: RNA-directed RNA polymerase
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Multimeric state: monomeric
Accessible surface area: 23451.92 Å2
Buried surface area: 1033.93 Å2
Dissociation area: 101.62 Å2
Dissociation energy (ΔGdiss): 8.12 kcal/mol
Dissociation entropy (TΔSdiss): -0.12 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-131655

Macromolecules

RNA-directed RNA polymerase
Chains: A, B
Length: 570 amino acids
Theoretical weight: 63.38 KDa
Source organism: Hepatitis C virus isolate HC-J4
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: O92972 (Residues: 2420-2989; Coverage: 19%)
Pfam: Viral RNA dependent RNA polymerase
InterPro:
RNA-directed RNA polymerase in PDB entry 4ry5, assembly 1, front view.
RNA-directed RNA polymerase in PDB entry 4ry5, assembly 1, side view.
RNA-directed RNA polymerase in PDB entry 4ry5, assembly 1, top view.
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