RNA dependent RNA polymerase, hepatitis C virus (IPR002166)

Short name: RNA_pol_HCV

Overlapping homologous superfamilies


Family relationships



The RNA dependent RNA polymerase is also known as non-structural protein NS5B. NS5B is a 65 kDa protein that resembles other viral RNA polymerases. Hepatitis C virus (HCV) replication is thought to occur in membrane bound replication complexes. These complexes transcribe the positive strand and the resulting minus strand is used as a template for the synthesis of genomic RNA. There are two viral proteins involved in the reaction, NS3 and NS5B [PMID: 9343198, PMID: 8598194, PMID: 9514871].

GO terms

Biological Process

GO:0039694 viral RNA genome replication

Molecular Function

GO:0003723 RNA binding
GO:0003968 RNA-directed 5'-3' RNA polymerase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.