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Crystal Structure of Human Presequence Protease in Complex with Inhibitor MitoBloCK-60

X-ray diffraction
2.265Å resolution
PDB entry 4rpu coloured by chain, front view.
PDB entry 4rpu coloured by chain, side view.
PDB entry 4rpu coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1
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Assembly Name: Presequence protease, mitochondrial
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Multimeric state: monomeric
PDBe Complex ID: PDB-CPX-177328
Assembly 2 (preferred)
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Assembly Name: Presequence protease, mitochondrial
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Multimeric state: monomeric
PDBe Complex ID: PDB-CPX-177328

Macromolecules

Presequence protease, mitochondrial
Chain: A
Length: 1014 amino acids
Theoretical weight: 115.82 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q5JRX3 (Residues: 33-1037; Coverage: 97%)
Gene names: KIAA1104, MP1, PITRM1, PREP
Pfam:
InterPro:
CATH: Metalloenzyme, LuxS/M16 peptidase-like
Presequence protease, mitochondrial in PDB entry 4rpu, assembly 1, front view.
Presequence protease, mitochondrial in PDB entry 4rpu, assembly 1, side view.
Presequence protease, mitochondrial in PDB entry 4rpu, assembly 1, top view.
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Presequence protease, mitochondrial
Chain: B
Length: 1014 amino acids
Theoretical weight: 115.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q5JRX3 (Residues: 33-1037; Coverage: 97%)
Gene names: KIAA1104, MP1, PITRM1, PREP
Pfam:
InterPro:
CATH: Metalloenzyme, LuxS/M16 peptidase-like
Presequence protease, mitochondrial in PDB entry 4rpu, assembly 2, front view.
Presequence protease, mitochondrial in PDB entry 4rpu, assembly 2, side view.
Presequence protease, mitochondrial in PDB entry 4rpu, assembly 2, top view.
Molecule details ›

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