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X-ray Structure of the Adduct formed between cisplatin and Ribonuclease A

X-ray diffraction
1.85Å resolution
PDB entry 4ot4 coloured by chain, front view.
PDB entry 4ot4 coloured by chain, side view.
PDB entry 4ot4 coloured by chain, top view.
Source organism: Bos taurus
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1
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Assembly Name: Ribonuclease pancreatic
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Multimeric state: monomeric
Accessible surface area: 6882.21 Å2
Buried surface area: 409.2 Å2
Dissociation area: 128.65 Å2
Dissociation energy (ΔGdiss): 21.9 kcal/mol
Dissociation entropy (TΔSdiss): 1.13 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-158390
Assembly 2 (preferred)
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Assembly Name: Ribonuclease pancreatic
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Multimeric state: monomeric
Accessible surface area: 6635.7 Å2
Buried surface area: 169.78 Å2
Dissociation area: 84.89 Å2
Dissociation energy (ΔGdiss): 10.91 kcal/mol
Dissociation entropy (TΔSdiss): 1.29 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-158390

Macromolecules

Ribonuclease pancreatic
Chains: A, B
Length: 124 amino acids
Theoretical weight: 13.71 KDa
Source organism: Bos taurus
Expression system: Not provided
UniProt:
  • Canonical: P61823 (Residues: 27-150; Coverage: 100%)
Gene names: RNASE1, RNS1
Pfam: Pancreatic ribonuclease
InterPro:
CATH: Ribonuclease A-like domain
Ribonuclease pancreatic in PDB entry 4ot4, assembly 2, front view.
Ribonuclease pancreatic in PDB entry 4ot4, assembly 2, side view.
Ribonuclease pancreatic in PDB entry 4ot4, assembly 2, top view.
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