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Murine IRGa6 bound to Toxoplasma ROP5C, a pseudokinase GDI

X-ray diffraction
1.72Å resolution
PDB entry 4lv8 coloured by chain, front view.
PDB entry 4lv8 coloured by chain, side view.
PDB entry 4lv8 coloured by chain, top view.
Source organisms:
Assemblies composition:
hetero dimer (preferred)
monomeric
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Interferon-inducible GTPase 1 and Protein kinase domain-containing protein
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Multimeric state: hetero dimer
Accessible surface area: 32884.41 Å2
Buried surface area: 5861.72 Å2
Dissociation area: 1,308.12 Å2
Dissociation energy (ΔGdiss): -13.48 kcal/mol
Dissociation entropy (TΔSdiss): 13.67 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-125220
Assembly 2
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Assembly Name: Protein kinase domain-containing protein
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Multimeric state: monomeric
Accessible surface area: 15974.77 Å2
Buried surface area: 1973.89 Å2
Dissociation area: 101.03 Å2
Dissociation energy (ΔGdiss): -2.54 kcal/mol
Dissociation entropy (TΔSdiss): -0.41 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-125219
Assembly 3
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Assembly Name: Interferon-inducible GTPase 1
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Multimeric state: monomeric
Accessible surface area: 19030.48 Å2
Buried surface area: 1766.99 Å2
Dissociation area: 93.52 Å2
Dissociation energy (ΔGdiss): -2.9 kcal/mol
Dissociation entropy (TΔSdiss): -0.27 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-193063

Macromolecules

Protein kinase domain-containing protein
Chain: A
Length: 371 amino acids
Theoretical weight: 41.35 KDa
Source organism: Toxoplasma gondii type I
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: I6ZQR7 (Residues: 175-541; Coverage: 70%)
Gene name: ROP5C
Pfam: Kinase-like
InterPro:
CATH:
Protein kinase domain-containing protein in PDB entry 4lv8, assembly 1, front view.
Protein kinase domain-containing protein in PDB entry 4lv8, assembly 1, side view.
Protein kinase domain-containing protein in PDB entry 4lv8, assembly 1, top view.
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Interferon-inducible GTPase 1
Chain: B
Length: 423 amino acids
Theoretical weight: 48.48 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9QZ85 (Residues: 1-413; Coverage: 100%)
Gene names: Iigp1, Irga6
Pfam: Interferon-inducible GTPase (IIGP)
InterPro:
CATH: P-loop containing nucleotide triphosphate hydrolases
Interferon-inducible GTPase 1 in PDB entry 4lv8, assembly 1, front view.
Interferon-inducible GTPase 1 in PDB entry 4lv8, assembly 1, side view.
Interferon-inducible GTPase 1 in PDB entry 4lv8, assembly 1, top view.
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