Protein kinase-like domain, Apicomplexa (IPR027916)

Short name: Kinase-like_dom_Apicomplexa

Overlapping homologous superfamilies

Domain relationships


This entry represents the kinase-like domain found in the Rhoptry (ROP) pseudokinases from the intracellular parasite Toxoplasma gondii [PMID: 23742205]. ROP2, ROP4 and ROP8 have a typical bi-lobed protein kinase fold, but lack catalytic activity [PMID: 19197235].

ROP4 is localised to the rhoptries, secretory organelles at the apical end of the parasite, and is secreted from the parasite during host cell invasion [PMID: 15470260]. ROP2 mediates an association between the parasitophorous vacuole (PV) and host cell mitochondria by inserting into the parasitophorous vacuole membrane (PVM) [PMID: 11448993]. It plays important roles in rhoptry biogenesis, parasite invasion, and intracellular replication [PMID: 12711703]. During host invasion, ROP2 is released from the vacuole membrane and becomes phosphorylated in the infected cells [PMID: 11448993].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.