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Uninhibited DNA-binding domain of the Ets transcription factor ERG

X-ray diffraction
1.7Å resolution
PDB entry 4irg coloured by chain, front view.
PDB entry 4irg coloured by chain, side view.
PDB entry 4irg coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Transcriptional regulator ERG
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Multimeric state: homo dimer
Accessible surface area: 10381.89 Å2
Buried surface area: 1974.84 Å2
Dissociation area: 987.42 Å2
Dissociation energy (ΔGdiss): 8.76 kcal/mol
Dissociation entropy (TΔSdiss): 11.09 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-145751

Macromolecules

Transcriptional regulator ERG
Chain: A
Length: 109 amino acids
Theoretical weight: 12.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P11308 (Residues: 306-405; Coverage: 21%)
Gene name: ERG
Pfam: Ets-domain
InterPro:
CATH: Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
Transcriptional regulator ERG in PDB entry 4irg, assembly 1, front view.
Transcriptional regulator ERG in PDB entry 4irg, assembly 1, side view.
Transcriptional regulator ERG in PDB entry 4irg, assembly 1, top view.
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