› › Structure analysis

Structure of the factor Xa-like trypsin variant triple-Ala (TGA) in complex with eglin C

X-ray diffraction
1.89Å resolution
PDB entry 4b2a coloured by chain, front view.
PDB entry 4b2a coloured by chain, side view.
PDB entry 4b2a coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Assembly Name: Eglin C and Serine protease 1
hide full assembly name
Multimeric state: hetero dimer
Accessible surface area: 11772.88 Å2
Buried surface area: 2515.26 Å2
Dissociation area: 902.3 Å2
Dissociation energy (ΔGdiss): 6.12 kcal/mol
Dissociation entropy (TΔSdiss): 10.8 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-133326
Assembly 2
Download    3D Visualisation
Assembly Name: Eglin C and Serine protease 1
hide full assembly name
Multimeric state: hetero dimer
Accessible surface area: 11894.04 Å2
Buried surface area: 2064.13 Å2
Dissociation area: 861.3 Å2
Dissociation energy (ΔGdiss): 5.73 kcal/mol
Dissociation entropy (TΔSdiss): 10.77 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-133326

Macromolecules

Serine protease 1
Chains: A, C
Length: 223 amino acids
Theoretical weight: 23.39 KDa
Source organism: Bos taurus
Expression system: Escherichia coli
UniProt:
  • Canonical: P00760 (Residues: 24-246; Coverage: 97%)
Gene names: PRSS1, TRP1, TRY1, TRYP1
Pfam: Trypsin
InterPro:
CATH: Trypsin-like serine proteases
Serine protease 1 in PDB entry 4b2a, assembly 1, front view.
Serine protease 1 in PDB entry 4b2a, assembly 1, side view.
Serine protease 1 in PDB entry 4b2a, assembly 1, top view.
Molecule details ›

Search similar proteins

Eglin C
Chains: B, D
Length: 66 amino acids
Theoretical weight: 7.68 KDa
Source organism: Hirudo medicinalis
Expression system: Escherichia coli
UniProt:
  • Canonical: P01051 (Residues: 5-70; Coverage: 94%)
Pfam: Potato inhibitor I family
InterPro:
CATH: Trypsin Inhibitor V, subunit A
Eglin C in PDB entry 4b2a, assembly 1, front view.
Eglin C in PDB entry 4b2a, assembly 1, side view.
Eglin C in PDB entry 4b2a, assembly 1, top view.
Molecule details ›

Search similar proteins

Quick links