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Clostridium difficile toxin A (TcdA) glucolsyltransferase domain

X-ray diffraction
2.202Å resolution
PDB entry 3ss1 coloured by chain, front view.
PDB entry 3ss1 coloured by chain, side view.
PDB entry 3ss1 coloured by chain, top view.
Source organism: Clostridioides difficile 630
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Toxin A
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Multimeric state: monomeric
Accessible surface area: 25424.97 Å2
Buried surface area: 140.05 Å2
Dissociation area: 70.02 Å2
Dissociation energy (ΔGdiss): 5.33 kcal/mol
Dissociation entropy (TΔSdiss): -0.13 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-147647

Macromolecules

Glucosyltransferase TcdA
Chain: A
Length: 555 amino acids
Theoretical weight: 64.4 KDa
Source organism: Clostridioides difficile 630
Expression system: Priestia megaterium
UniProt:
  • Canonical: P16154 (Residues: 1-542; Coverage: 20%)
Gene names: tcdA, toxA
Pfam:
InterPro:
CATH: Methane Monooxygenase Hydroxylase; Chain G, domain 1
Glucosyltransferase TcdA in PDB entry 3ss1, assembly 1, front view.
Glucosyltransferase TcdA in PDB entry 3ss1, assembly 1, side view.
Glucosyltransferase TcdA in PDB entry 3ss1, assembly 1, top view.
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