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Crystal structure of the mutant R160A,V182A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with the inhibitor BMP

X-ray diffraction
1.321Å resolution
PDB entry 3qmr coloured by chain, front view.
PDB entry 3qmr coloured by chain, side view.
PDB entry 3qmr coloured by chain, top view.
Source organism: Methanothermobacter thermautotrophicus str. Delta H
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Orotidine 5'-phosphate decarboxylase
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Multimeric state: homo dimer
Accessible surface area: 15900.91 Å2
Buried surface area: 4873.54 Å2
Dissociation area: 1,843.78 Å2
Dissociation energy (ΔGdiss): 32.47 kcal/mol
Dissociation entropy (TΔSdiss): 12.99 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-127822

Macromolecules

Orotidine 5'-phosphate decarboxylase
Chains: A, B
Length: 228 amino acids
Theoretical weight: 24.77 KDa
Source organism: Methanothermobacter thermautotrophicus str. Delta H
Expression system: Escherichia coli
UniProt:
  • Canonical: O26232 (Residues: 1-228; Coverage: 100%)
Gene names: MTH_129, pyrF
Pfam: Orotidine 5'-phosphate decarboxylase / HUMPS family
InterPro:
CATH: Aldolase class I
Orotidine 5'-phosphate decarboxylase in PDB entry 3qmr, assembly 1, front view.
Orotidine 5'-phosphate decarboxylase in PDB entry 3qmr, assembly 1, side view.
Orotidine 5'-phosphate decarboxylase in PDB entry 3qmr, assembly 1, top view.
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