Orotidine 5'-phosphate decarboxylase domain (IPR001754)

Short name: OMPdeCOase_dom

Overlapping homologous superfamilies

Domain relationships


Orotidine 5'-phosphate decarboxylase (OMPdecase) [PMID: 2835631, PMID: 1730672] catalyses the last step in the de novo biosynthesis of pyrimidines, the decarboxylation of OMP into UMP. In higher eukaryotes OMPdecase is part, with orotate phosphoribosyltransferase, of a bifunctional enzyme, while the prokaryotic and fungal OMPdecases are monofunctional protein.

Some parts of the sequence of OMPdecase are well conserved across species. The best conserved region is located in the N-terminal half of OMPdecases and is centred around a lysine residue which is essential for the catalytic function of the enzyme.

This entry also includes enzymes such as 3-hexulose-6-phosphate synthase EC: and 3-keto-L-gulonate-6-phosphate decarboxylase EC:

GO terms

Biological Process

GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process

Molecular Function

GO:0004590 orotidine-5'-phosphate decarboxylase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.