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Crystal structure of RabGGTase(DELTA LRR; DELTA IG) in Complex with BMS3 and lipid substrate GGPP

X-ray diffraction
2.35Å resolution
PDB entry 3pz2 coloured by chain, front view.
PDB entry 3pz2 coloured by chain, side view.
PDB entry 3pz2 coloured by chain, top view.
Source organism: Rattus norvegicus
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Protein geranylgeranyltransferase type II complex
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Multimeric state: hetero dimer
Accessible surface area: 25123.24 Å2
Buried surface area: 5508.61 Å2
Dissociation area: 2,202.19 Å2
Dissociation energy (ΔGdiss): 18.8 kcal/mol
Dissociation entropy (TΔSdiss): 13.89 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-170665
Complex Portal ID: CPX-2249

Macromolecules

Geranylgeranyl transferase type-2 subunit alpha
Chain: A
Length: 332 amino acids
Theoretical weight: 38.5 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q08602 (Residues: 1-237, 353-441; Coverage: 58%)
Gene names: Ggta, Rabggta
Pfam: Protein prenyltransferase alpha subunit repeat
InterPro: Protein prenyltransferase, alpha subunit
CATH: Protein prenylyltransferase
Geranylgeranyl transferase type-2 subunit alpha in PDB entry 3pz2, assembly 1, front view.
Geranylgeranyl transferase type-2 subunit alpha in PDB entry 3pz2, assembly 1, side view.
Geranylgeranyl transferase type-2 subunit alpha in PDB entry 3pz2, assembly 1, top view.
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Geranylgeranyl transferase type-2 subunit beta
Chain: B
Length: 330 amino acids
Theoretical weight: 36.76 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q08603 (Residues: 2-331; Coverage: 100%)
Gene names: Ggtb, Rabggtb
Pfam: Prenyltransferase and squalene oxidase repeat
InterPro:
CATH: Glycosyltransferase
Geranylgeranyl transferase type-2 subunit beta in PDB entry 3pz2, assembly 1, front view.
Geranylgeranyl transferase type-2 subunit beta in PDB entry 3pz2, assembly 1, side view.
Geranylgeranyl transferase type-2 subunit beta in PDB entry 3pz2, assembly 1, top view.
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