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Crystal structure of RabGGTase(DELTA LRR; DELTA IG) in Complex with BMS3 and lipid substrate GGPP

Source organism: Rattus norvegicus
Biochemical function: protein prenyltransferase activity
Biological process: protein geranylgeranylation
Cellular component: Rab-protein geranylgeranyltransferase complex

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EC 2.5.1.60: Protein geranylgeranyltransferase type II

Reaction catalysed:
Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate
Systematic name:
Geranylgeranyl-diphosphate:protein-cysteine geranyltransferase
Alternative Name(s):
  • GGTaseII
  • Rab geranylgeranyltransferase
  • RabGGTase
  • Type II protein geranyl-geranyltransferase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00432
Domain description: Prenyltransferase and squalene oxidase repeat
Occurring in:
  1. Geranylgeranyl transferase type-2 subunit beta
The deposited structure of PDB entry 3pz2 contains 5 copies of Pfam domain PF00432 (Prenyltransferase and squalene oxidase repeat) in Geranylgeranyl transferase type-2 subunit beta. Showing 5 copies in chain B.

PF01239
Domain description: Protein prenyltransferase alpha subunit repeat
Occurring in:
  1. Geranylgeranyl transferase type-2 subunit alpha
The deposited structure of PDB entry 3pz2 contains 5 copies of Pfam domain PF01239 (Protein prenyltransferase alpha subunit repeat) in Geranylgeranyl transferase type-2 subunit alpha. Showing 5 copies in chain A.

InterPro InterPro annotations
IPR002088
Domain description: Protein prenyltransferase, alpha subunit
Occurring in:
  1. Geranylgeranyl transferase type-2 subunit alpha
IPR001330
Domain description: PFTB repeat
Occurring in:
  1. Geranylgeranyl transferase type-2 subunit beta
IPR045089
Domain description: Prenyltransferase subunit beta
Occurring in:
  1. Geranylgeranyl transferase type-2 subunit beta
IPR026873
Domain description: Geranylgeranyl transferase type-2 subunit beta
Occurring in:
  1. Geranylgeranyl transferase type-2 subunit beta
IPR008930
Domain description: Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
Occurring in:
  1. Geranylgeranyl transferase type-2 subunit beta

Structure domains

CATH CATH domains
1.50.10.20
Class: Mainly Alpha
Architecture: Alpha/alpha barrel
Topology: Glycosyltransferase
Homology: Glycosyltransferase
Occurring in:
  1. Geranylgeranyl transferase type-2 subunit beta
The deposited structure of PDB entry 3pz2 contains 1 copy of CATH domain 1.50.10.20 (Glycosyltransferase) in Geranylgeranyl transferase type-2 subunit beta. Showing 1 copy in chain B.
1.25.40.120
Class: Mainly Alpha
Architecture: Alpha Horseshoe
Topology: Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
Homology: Protein prenylyltransferase
Occurring in:
  1. Geranylgeranyl transferase type-2 subunit alpha
The deposited structure of PDB entry 3pz2 contains 1 copy of CATH domain 1.25.40.120 (Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat) in Geranylgeranyl transferase type-2 subunit alpha. Showing 1 copy in chain A.

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