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The Crystal Structure of Spot14, a modulator of lipogenesis

X-ray diffraction
2.65Å resolution
PDB entry 3ont coloured by chain, front view.
PDB entry 3ont coloured by chain, side view.
PDB entry 3ont coloured by chain, top view.
Source organism: Mus musculus
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Thyroid hormone-inducible hepatic protein
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Multimeric state: homo dimer
Accessible surface area: 12585.68 Å2
Buried surface area: 5302.52 Å2
Dissociation area: 2,651.26 Å2
Dissociation energy (ΔGdiss): 53.66 kcal/mol
Dissociation entropy (TΔSdiss): 12.69 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-178929

Macromolecules

Thyroid hormone-inducible hepatic protein
Chain: A
Length: 152 amino acids
Theoretical weight: 17.54 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q62264 (Residues: 1-150; Coverage: 100%)
Gene names: S14, Thrsp
Pfam: Thyroid hormone-inducible hepatic protein Spot 14
InterPro: Spot 14 family
CATH: Helix Hairpins
Thyroid hormone-inducible hepatic protein in PDB entry 3ont, assembly 1, front view.
Thyroid hormone-inducible hepatic protein in PDB entry 3ont, assembly 1, side view.
Thyroid hormone-inducible hepatic protein in PDB entry 3ont, assembly 1, top view.
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