Spot 14 family (IPR009786)

Short name: Spot_14

Overlapping homologous superfamilies


Family relationships



The Spot 14 family includes thyroid hormone-inducible hepatic protein (Spot 14), Mid1-interacting protein and related sequneces. Mainly expressed in tissues that synthesise triglycerides, the mRNA coding for Spot 14 has been shown to be increased in rat liver by insulin, dietary carbohydrates, glucose in hepatocyte culture medium, as well as thyroid hormone. In contrast, dietary fats and polyunsaturated fatty acids, have been shown to decrease the amount of Spot 14 mRNA, while an elevated level of cAMP acts as a dominant negative factor. In addition, liver-specific factors or chromatin organisation of the gene have been shown to contribute to the regulation of its expression [PMID: 9003802]. Spot 14 protein is thought to be required for induction of hepatic lipogenesis [PMID: 11564699]. Mid1-interacting protein is involved in stabilisation of microtubules [PMID: 15070402].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.