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Crystal structure of the sialyltransferase CST-II in complex with trisaccharide acceptor and CMP

X-ray diffraction
1.95Å resolution
PDB entry 2x61 coloured by chain, front view.
PDB entry 2x61 coloured by chain, side view.
PDB entry 2x61 coloured by chain, top view.
Source organism: Campylobacter jejuni
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Alpha-2,3/8-sialyltransferase
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Multimeric state: homo tetramer
Accessible surface area: 42399.61 Å2
Buried surface area: 16101.49 Å2
Dissociation area: 3,195.51 Å2
Dissociation energy (ΔGdiss): 10.13 kcal/mol
Dissociation entropy (TΔSdiss): 40.81 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-192239
Assembly 2
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Assembly Name: Alpha-2,3/8-sialyltransferase
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Multimeric state: homo tetramer
Accessible surface area: 42415.77 Å2
Buried surface area: 14226.04 Å2
Dissociation area: 3,103.1 Å2
Dissociation energy (ΔGdiss): 0.47 kcal/mol
Dissociation entropy (TΔSdiss): 40.72 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-192239

Macromolecules

Alpha-2,3/8-sialyltransferase
Chains: A, B
Length: 258 amino acids
Theoretical weight: 30.4 KDa
Source organism: Campylobacter jejuni
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9LAK3 (Residues: 1-258; Coverage: 89%)
Gene name: cst-II
Pfam: Alpha-2,3-sialyltransferase (CST-I)
InterPro:
CATH: Alpha-2,3-sialyltransferase
Alpha-2,3/8-sialyltransferase in PDB entry 2x61, assembly 1, front view.
Alpha-2,3/8-sialyltransferase in PDB entry 2x61, assembly 1, side view.
Alpha-2,3/8-sialyltransferase in PDB entry 2x61, assembly 1, top view.
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