Alpha-2,3-sialyltransferase (IPR009251)

Short name: A-2_3-sialyltransferase

Overlapping homologous superfamilies

Family relationships



This entry represents several alpha-2,3-sialyltransferase (EC:2.4.99) proteins, most of which are found in the food-borne pathogen Campylobacter jejuni. Sialyltransferases transfer a sialic acid moiety from cytidine-5'-monophospho-N-acetyl-neuraminic acid (CMP-NeuAc) to terminal positions of various key glycoconjugates, which play critical roles in cell recognition and adherence [PMID: 14730352]. The structure of Cst-II alpha-2,3-sialyltransferase from C. jejuni consists of a 3-layer alpha/beta/alpha topology. Cst-II catalytic mechanism involves an essential histidine (general base) and two tyrosine residues (coordination of the phosphate leaving group) to carry out substrate binding and glycosyl transfer.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.