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Na in the active site of DNA Polymerase lambda

X-ray diffraction
1.9Å resolution
PDB entry 2pfn coloured by chain, front view.
PDB entry 2pfn coloured by chain, side view.
PDB entry 2pfn coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule
3 distinct DNA molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: DNA polymerase lambda and DNA
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Multimeric state: hetero tetramer
Accessible surface area: 16761.61 Å2
Buried surface area: 6062.59 Å2
Dissociation area: 1,452.47 Å2
Dissociation energy (ΔGdiss): 26.23 kcal/mol
Dissociation entropy (TΔSdiss): 10.28 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-115760

Macromolecules

DNA polymerase lambda
Chain: A
Length: 335 amino acids
Theoretical weight: 37.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UGP5 (Residues: 242-575; Coverage: 58%)
Gene name: POLL
Pfam:
InterPro:
CATH:
SCOP:
DNA polymerase lambda in PDB entry 2pfn, assembly 1, front view.
DNA polymerase lambda in PDB entry 2pfn, assembly 1, side view.
DNA polymerase lambda in PDB entry 2pfn, assembly 1, top view.
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DNA chain T
Name: Template
Representative chains: T
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 11 nucleotides
Theoretical weight: 3.37 KDa
Template in PDB entry 2pfn, assembly 1, front view.
Template in PDB entry 2pfn, assembly 1, side view.
Template in PDB entry 2pfn, assembly 1, top view.
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DNA chain P
Name: Primer
Representative chains: P
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 6 nucleotides
Theoretical weight: 1.79 KDa
Primer in PDB entry 2pfn, assembly 1, front view.
Primer in PDB entry 2pfn, assembly 1, side view.
Primer in PDB entry 2pfn, assembly 1, top view.
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DNA chain D
Name: Downstream Primer
Representative chains: D
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 4 nucleotides
Theoretical weight: 1.19 KDa
Downstream Primer in PDB entry 2pfn, assembly 1, front view.
Downstream Primer in PDB entry 2pfn, assembly 1, side view.
Downstream Primer in PDB entry 2pfn, assembly 1, top view.
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