DNA polymerase lambda, fingers domain (IPR018944)

Short name: DNA_pol_lambd_fingers_domain

Overlapping homologous superfamilies


Domain relationships



DNA polymerases catalyse the addition of dNMPs onto the 3-prime ends of DNA chains. There is a general polymerase fold consisting of three subdomains that have been likened to the fingers, palm, and thumb of a right hand. This entry represents the central three-helical region of DNA polymerase lambda referred to as the F and G helices of the fingers domain. Contacts with DNA involve this conserved helix-hairpin-helix motif in the fingers region which interacts with the primer strand. This motif is common to several DNA binding proteins and confers a sequence-independent interaction with the DNA backbone [PMID: 14992725].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003677 DNA binding
GO:0034061 DNA polymerase activity

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.