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CRYSTAL STRUCTURE OF HUMAN STE20-LIKE KINASE (DIPHOSPHORYLATED FORM) BOUND TO 5- AMINO-3-((4-(AMINOSULFONYL)PHENYL)AMINO)-N-(2,6- DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE

X-ray diffraction
2.2Å resolution
PDB entry 2jfl coloured by chain, front view.
PDB entry 2jfl coloured by chain, side view.
PDB entry 2jfl coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: STE20-like serine/threonine-protein kinase
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Multimeric state: homo dimer
Accessible surface area: 26101.16 Å2
Buried surface area: 8787.43 Å2
Dissociation area: 2,133.28 Å2
Dissociation energy (ΔGdiss): 12.04 kcal/mol
Dissociation entropy (TΔSdiss): 13.92 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-190547

Macromolecules

STE20-like serine/threonine-protein kinase
Chain: A
Length: 325 amino acids
Theoretical weight: 37.32 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9H2G2 (Residues: 12-15, 16-320; Coverage: 25%)
Gene names: KIAA0204, SLK, STK2
Pfam: Protein kinase domain
InterPro:
CATH:
SCOP: Protein kinases, catalytic subunit
STE20-like serine/threonine-protein kinase in PDB entry 2jfl, assembly 1, front view.
STE20-like serine/threonine-protein kinase in PDB entry 2jfl, assembly 1, side view.
STE20-like serine/threonine-protein kinase in PDB entry 2jfl, assembly 1, top view.
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