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Crystal Structure of the Zinc-Beta-Lactamase L1 from Stenotrophomonas Maltophilia (Inhibitor 3)

Source organism: Stenotrophomonas maltophilia
Biochemical function: metal ion binding
Biological process: response to antibiotic
Cellular component: periplasmic space

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EC 3.5.2.6: Beta-lactamase

Reaction catalysed:
A beta-lactam + H(2)O = a substituted beta-amino acid
Systematic name:
Beta-lactam hydrolase
Alternative Name(s):
  • Ampicillinase
  • Beta-lactamase A, B, C
  • Beta-lactamase AME I
  • Beta-lactamase I-III
  • Cephalosporin-beta-lactamase
  • Cephalosporinase
  • Exopenicillinase
  • Neutrapen
  • Penicillin amido-beta-lactamhydrolase
  • Penicillin beta-lactamase
  • Penicillinase
  • Penicillinase I, II

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00753
Domain description: Metallo-beta-lactamase superfamily
Occurring in:
  1. Metallo-beta-lactamase L1 type 3
The deposited structure of PDB entry 2hb9 contains 1 copy of Pfam domain PF00753 (Metallo-beta-lactamase superfamily) in Metallo-beta-lactamase L1 type 3. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001279
Domain description: Metallo-beta-lactamase
Occurring in:
  1. Metallo-beta-lactamase L1 type 3
IPR036866
Domain description: Ribonuclease Z/Hydroxyacylglutathione hydrolase-like
Occurring in:
  1. Metallo-beta-lactamase L1 type 3
IPR001018
Domain description: Beta-lactamase, class-B, conserved site
Occurring in:
  1. Metallo-beta-lactamase L1 type 3

Structure domain

CATH CATH domain
3.60.15.10
Class: Alpha Beta
Architecture: 4-Layer Sandwich
Topology: Metallo-beta-lactamase; Chain A
Homology: Ribonuclease Z/Hydroxyacylglutathione hydrolase-like
Occurring in:
  1. Metallo-beta-lactamase L1 type 3
The deposited structure of PDB entry 2hb9 contains 1 copy of CATH domain 3.60.15.10 (Metallo-beta-lactamase; Chain A) in Metallo-beta-lactamase L1 type 3. Showing 1 copy in chain A.
SCOP SCOP annotation
56282
Class: Alpha and beta proteins (a+b)
Fold: Metallo-hydrolase/oxidoreductase
Superfamily: Metallo-hydrolase/oxidoreductase
Occurring in:
  1. Metallo-beta-lactamase L1 type 3
The deposited structure of PDB entry 2hb9 contains 1 copy of SCOP domain 56282 (Zn metallo-beta-lactamase) in Metallo-beta-lactamase L1 type 3. Showing 1 copy in chain A.

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