Homologous Superfamily

Metallo-hydrolase/oxidoreductase superfamily (IPR036866)

Short name: Metallo-hydrolase/OxRdtase

Description

Proteins in this superfamily contains a fold consisted of duplication of beta(4)-alpha-beta-alpha motif. Apart from the beta-lactamases and metallo-beta-lactamases, a number of other proteins also contain this fold [PMID: 7588620]. These proteins include thiolesterases, members of the glyoxalase II family, that catalyse the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid and a competence protein that is essential for natural transformation in Neisseria gonorrhoeae and could be a transporter involved in DNA uptake. Except for the competence protein these proteins bind two zinc ions per molecule as cofactor.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
SUPERFAMILY
GENE3D