Conserved Site

Beta-lactamase, class-B, conserved site (IPR001018)

Short name: Beta-lactamase_class-B_CS

Description

Synonym(s): Penicillinase, Cephalosporinase

Beta-lactamases (EC:3.5.2.6) are enzymes which catalyse the hydrolysis of an amide bond in the beta-lactam ring of antibiotics belonging to the penicillin/cephalosporin family. The class B enzymes are zinc containing proteins whilst class A, C and D enzymes are serine hydrolases. Class B beta-lactamases have been described in several Gram-negative bacterial species; they seem to share the characteristic of being able to hydrolyse carbapenem compounds, new beta-lactam antibiotics of great therapeutic potential.

The conserved regions in the sequence of known class B beta-lactamases are centred on residues known to be involved in binding the zinc ion essential for the enzymes catalytic activity [PMID: 8141584, PMID: 8805566].

GO terms

Biological Process

GO:0017001 antibiotic catabolic process

Molecular Function

GO:0008800 beta-lactamase activity
GO:0008270 zinc ion binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns
PROSITE patterns