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Crystal structure of translation initiation factor aIF2betagamma heterodimer with GDP

Source organism: Pyrococcus furiosus DSM 3638
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

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EC 3.6.5.3: Protein-synthesizing GTPase

Reaction catalysed:
GTP + H(2)O = GDP + phosphate
Systematic name:
GTP phosphohydrolase (mRNA-translation-assisting)
Alternative Name(s):
  • Elongation factor (EF)
  • Initiation factor (IF)
  • Peptide-release factor (RF)
  • Peptide-release or termination factor

GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF01873
Domain description: Domain found in IF2B/IF5
Occurring in:
  1. Translation initiation factor 2 subunit beta
The deposited structure of PDB entry 2dcu contains 1 copy of Pfam domain PF01873 (Domain found in IF2B/IF5) in Translation initiation factor 2 subunit beta. Showing 1 copy in chain B.

PF09173
Domain description: Initiation factor eIF2 gamma, C terminal
Occurring in:
  1. Translation initiation factor 2 subunit gamma
The deposited structure of PDB entry 2dcu contains 1 copy of Pfam domain PF09173 (Initiation factor eIF2 gamma, C terminal) in Translation initiation factor 2 subunit gamma. Showing 1 copy in chain A.

PF03144
Domain description: Elongation factor Tu domain 2
Occurring in:
  1. Translation initiation factor 2 subunit gamma
The deposited structure of PDB entry 2dcu contains 1 copy of Pfam domain PF03144 (Elongation factor Tu domain 2) in Translation initiation factor 2 subunit gamma. Showing 1 copy in chain A.

PF00009
Domain description: Elongation factor Tu GTP binding domain
Occurring in:
  1. Translation initiation factor 2 subunit gamma
The deposited structure of PDB entry 2dcu contains 1 copy of Pfam domain PF00009 (Elongation factor Tu GTP binding domain) in Translation initiation factor 2 subunit gamma. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000795
Domain description: Translational (tr)-type GTP-binding domain
Occurring in:
  1. Translation initiation factor 2 subunit gamma
IPR002735
Domain description: Translation initiation factor IF2/IF5 domain
Occurring in:
  1. Translation initiation factor 2 subunit beta
IPR004458
Domain description: Translation initiation factor 2, beta subunit
Occurring in:
  1. Translation initiation factor 2 subunit beta
IPR015256
Domain description: Initiation factor eIF2 gamma, C-terminal
Occurring in:
  1. Translation initiation factor 2 subunit gamma
IPR022424
Domain description: Translation initiation factor 2, gamma subunit
Occurring in:
  1. Translation initiation factor 2 subunit gamma
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Translation initiation factor 2 subunit gamma
IPR016190
Domain description: Translation initiation factor IF2/IF5, zinc-binding
Occurring in:
  1. Translation initiation factor 2 subunit beta
IPR045196
Domain description: Translation initiation factor IF2/IF5
Occurring in:
  1. Translation initiation factor 2 subunit beta
IPR016189
Domain description: Translation initiation factor IF2/IF5, N-terminal
Occurring in:
  1. Translation initiation factor 2 subunit beta
IPR009001
Domain description: Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal
Occurring in:
  1. Translation initiation factor 2 subunit gamma
IPR004161
Domain description: Translation elongation factor EFTu-like, domain 2
Occurring in:
  1. Translation initiation factor 2 subunit gamma
IPR044127
Domain description: Initiation factor eIF2 gamma, domain 2
Occurring in:
  1. Translation initiation factor 2 subunit gamma
IPR009000
Domain description: Translation protein, beta-barrel domain superfamily
Occurring in:
  1. Translation initiation factor 2 subunit gamma
IPR044128
Domain description: Initiation factor eIF2 gamma, GTP-binding domain
Occurring in:
  1. Translation initiation factor 2 subunit gamma
IPR005225
Domain description: Small GTP-binding protein domain
Occurring in:
  1. Translation initiation factor 2 subunit gamma

Structure domains

CATH CATH domains
2.40.30.10
Class: Mainly Beta
Architecture: Beta Barrel
Topology: Elongation Factor Tu (Ef-tu); domain 3
Homology: Translation factors
Occurring in:
  1. Translation initiation factor 2 subunit gamma
The deposited structure of PDB entry 2dcu contains 2 copies of CATH domain 2.40.30.10 (Elongation Factor Tu (Ef-tu); domain 3) in Translation initiation factor 2 subunit gamma. Showing 2 copies in chain A.
3.30.70.3150
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Alpha-Beta Plaits
Homology: Alpha-Beta Plaits
Occurring in:
  1. Translation initiation factor 2 subunit beta
The deposited structure of PDB entry 2dcu contains 1 copy of CATH domain 3.30.70.3150 (Alpha-Beta Plaits) in Translation initiation factor 2 subunit beta. Showing 1 copy in chain B.
3.40.50.300
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: P-loop containing nucleotide triphosphate hydrolases
Occurring in:
  1. Translation initiation factor 2 subunit gamma
The deposited structure of PDB entry 2dcu contains 1 copy of CATH domain 3.40.50.300 (Rossmann fold) in Translation initiation factor 2 subunit gamma. Showing 1 copy in chain A.

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