Homologous Superfamily

Translation initiation factor IF2/IF5, N-terminal (IPR016189)

Short name: Transl_init_fac_IF2/IF5_N

Overlapping entries


The beta subunit of archaeal and eukaryotic translation initiation factor 2 (IF2beta) and the N-terminal domain of translation initiation factor 5 (IF5) show significant sequence homology [PMID: 11980477]. Archaeal IF2beta contains two independent structural domains: an N-terminal mixed alpha/beta core domain (topological similarity to the common core of ribosomal proteins L23 and L15e), and a C-terminal domain consisting of a zinc-binding C4 finger [PMID: 14978306]. Archaeal IF2beta is a ribosome-dependent GTPase that stimulates the binding of initiator Met-tRNA(i)(Met) to the ribosomes, even in the absence of other factors [PMID: 17608795]. The C-terminal domain of eukaryotic IF5 is involved in the formation of the multi-factor complex (MFC), an important intermediate for the 43S pre-initiation complex assembly [PMID: 16781736]. IF5 interacts directly with IF1, IF2beta and IF3c, which together with IF2-bound Met-tRNA(i)(Met) form the MFC.

This superfamily represents the N-terminal alpha/beta domain found in IF2beta and IF5.

GO terms

Biological Process

GO:0006413 translational initiation

Molecular Function

GO:0003743 translation initiation factor activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.