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Crystal Structure of the free human NKG2D immunoreceptor

X-ray diffraction
2.5Å resolution
PDB entry 1mpu coloured by chain, front view.
PDB entry 1mpu coloured by chain, side view.
PDB entry 1mpu coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: NKG2-D type II integral membrane protein
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Multimeric state: homo dimer
Accessible surface area: 13013.0 Å2
Buried surface area: 3221.44 Å2
Dissociation area: 1,405.34 Å2
Dissociation energy (ΔGdiss): 16.43 kcal/mol
Dissociation entropy (TΔSdiss): 11.96 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-150834

Macromolecules

NKG2-D type II integral membrane protein
Chain: A
Length: 138 amino acids
Theoretical weight: 15.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P26718 (Residues: 79-216; Coverage: 64%)
Gene names: D12S2489E, KLRK1, NKG2D
Pfam: Lectin C-type domain
InterPro:
CATH: Mannose-Binding Protein A, subunit A
SCOP: C-type lectin domain
NKG2-D type II integral membrane protein in PDB entry 1mpu, assembly 1, front view.
NKG2-D type II integral membrane protein in PDB entry 1mpu, assembly 1, side view.
NKG2-D type II integral membrane protein in PDB entry 1mpu, assembly 1, top view.
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